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Molecular Profile SMARCA4 del
Therapy PRT3789
Indication/Tumor Type lung non-small cell carcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
SMARCA4 del lung non-small cell carcinoma predicted - sensitive PRT3789 Preclinical - Pdx & cell culture Actionable In a preclinical study, PRT3789 inhibited proliferation of non-small cell lung cancer cells with deletion of SMARCA4 in culture and inhibited tumor growth in cell line xenograft and patient-derived xenograft (PDX) models (Cancer Res 2022;82(12_Suppl):Abstract nr 3263). detail...
PubMed Id Reference Title Details
Abstract 3263: Preclinical characterization of PRT3789, a potent and selective SMARCA2 targeted degrader Full reference...