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| Molecular Profile | SMARCA4 del |
| Therapy | PRT3789 |
| Indication/Tumor Type | lung non-small cell carcinoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| SMARCA4 del | lung non-small cell carcinoma | predicted - sensitive | PRT3789 | Preclinical - Pdx & cell culture | Actionable | In a preclinical study, PRT3789 inhibited proliferation of non-small cell lung cancer cells with deletion of SMARCA4 in culture and inhibited tumor growth in cell line xenograft and patient-derived xenograft (PDX) models (Cancer Res 2022;82(12_Suppl):Abstract nr 3263). | detail... |
| PubMed Id | Reference Title | Details |
|---|---|---|
| Abstract 3263: Preclinical characterization of PRT3789, a potent and selective SMARCA2 targeted degrader | Full reference... |