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Therapy Name PRT3789
Synonyms
Therapy Description

PRT3789 is a SMARCA2 degrader, which potentially decreases proliferation of tumor cells with SMARCA4 loss and inhibits tumor growth (Cancer Res 2022;82(12_Suppl):Abstract nr 3263).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
PRT3789 PRT-3789|PRT 3789 PRT3789 is a SMARCA2 degrader, which potentially decreases proliferation of tumor cells with SMARCA4 loss and inhibits tumor growth (Cancer Res 2022;82(12_Suppl):Abstract nr 3263).

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
SMARCA4 del lung non-small cell carcinoma predicted - sensitive PRT3789 Preclinical - Pdx & cell culture Actionable In a preclinical study, PRT3789 inhibited proliferation of non-small cell lung cancer cells with deletion of SMARCA4 in culture and inhibited tumor growth in cell line xenograft and patient-derived xenograft (PDX) models (Cancer Res 2022;82(12_Suppl):Abstract nr 3263). detail...
SMARCA4 mutant lung non-small cell carcinoma predicted - sensitive PRT3789 Phase I Actionable In a Phase I trial, PRT3789 treatment was well tolerated and resulted in partial responses, tumor shrinkage, and prolonged stable disease in patients with advanced esophageal cancer (N=2) or non-small cell lung cancer (N=18) harboring SMARCA4 mutations (Ann Oncol (2024) 35 (suppl_2): S483-S484; NCT05639751). detail...
SMARCA4 mutant esophageal cancer predicted - sensitive PRT3789 Case Reports/Case Series Actionable In a Phase I trial, PRT3789 treatment was well tolerated and resulted in partial responses, tumor shrinkage, and prolonged stable disease in patients with advanced esophageal cancer (N=2) or non-small cell lung cancer (N=18) harboring SMARCA4 mutations (Ann Oncol (2024) 35 (suppl_2): S483-S484; NCT05639751). detail...

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05639751 Phase I Docetaxel + PRT3789 PRT3789 PRT3789 Monotherapy and in Combo w/Docetaxel in Participants w/Advanced or Metastatic Solid Tumors w/SMARCA4 Mutation Recruiting USA | NLD | FRA | ESP 1


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