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Profile Name | SMARCA4 del |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
SMARCA4 del | lung non-small cell carcinoma | predicted - sensitive | PRT3789 | Preclinical - Pdx & cell culture | Actionable | In a preclinical study, PRT3789 inhibited proliferation of non-small cell lung cancer cells with deletion of SMARCA4 in culture and inhibited tumor growth in cell line xenograft and patient-derived xenograft (PDX) models (Cancer Res 2022;82(12_Suppl):Abstract nr 3263). | detail... | |
SMARCA4 del | melanoma | sensitive | SMD-3040 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, SMD-3040 inhibited proliferation of a melanoma cell line with SMARCA4 deletion in culture, and inhibited tumor growth in a cell line xenograft model (PMID: 37523716). | 37523716 | |
SMARCA4 del | lung non-small cell carcinoma | sensitive | SMD-3040 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, SMD-3040 inhibited proliferation of a non-small cell lung cancer cell line with SMARCA4 deletion in culture, and inhibited tumor growth in a cell line xenograft model (PMID: 37523716). | 37523716 |