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Molecular Profile | JAK2 V617F |
Therapy | Crizotinib |
Indication/Tumor Type | polycythemia vera |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
JAK2 V617F | polycythemia vera | sensitive | Crizotinib | Preclinical - Patient cell culture | Actionable | In a preclinical study, Xalkori (crizotinib) inhibited colony formation and Stat5 phosphorylation in polycythemia vera cultured cells derived from an EML4-ALK-positive non-small cell lung cancer patient who was diagnosed with polycythemia vera and found to harbor JAK2 V617F (PMID: 36537918). | 36537918 |
PubMed Id | Reference Title | Details |
---|---|---|
(36537918) | Crizotinib Has Preclinical Efficacy in Philadelphia-Negative Myeloproliferative Neoplasms. | Full reference... |