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ID DOID:8997
Name polycythemia vera
Definition A myeloproliferative neoplasm characterized by erythroid hyperplasia, myeloid leukocytosis, thrombocytosis, and splenomegaly.
Source DiseaseOntology.org
Alt Ids DOID:11868
Path disease disease of cellular proliferation cancer organ system cancer hematologic cancer bone marrow cancer myeloid neoplasm myeloproliferative neoplasm polycythemia vera

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
JAK2 V617F Ropeginterferon polycythemia vera sensitive detail...
IDH1 mutant N/A polycythemia vera not applicable detail...
IDH2 mutant N/A polycythemia vera not applicable detail...
JAK2 V617F INCB053914 polycythemia vera predicted - sensitive detail...
JAK2 V617F N/A polycythemia vera not applicable detail...
JAK2 exon12 N/A polycythemia vera not applicable detail...
JAK2 V617F C220 polycythemia vera predicted - sensitive detail...
JAK2 V617F C220 + Ruxolitinib polycythemia vera predicted - sensitive detail...
JAK2 V617F Binimetinib + Ruxolitinib polycythemia vera sensitive detail...
JAK2 V617F Binimetinib + CHZ868 polycythemia vera sensitive detail...
JAK2 V617F Crizotinib polycythemia vera sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02038036 Phase III Peginterferon alfa-2b Anagrelide Hydroxyurea Pipobroman Ruxolitinib Ruxolitinib Efficacy and Safety in Patients With HU Resistant or Intolerant Polycythemia Vera vs Best Available Therapy. (RESPONSE-2) Completed TUR | ITA | ISR | HUN | FRA | ESP | DEU | CAN | BEL | AUS 2
NCT02493530 Phase I Ruxolitinib + Umbralisib TGR-1202 + Ruxolitinib PMF PPV-MF PET-MF MDS/MPN Polycythemia Vera Resistant to Hydroxyurea Completed USA 0
NCT03287245 Phase II Idasanutlin A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Idasanutlin Monotherapy in Participants With Hydroxyurea-Resistant/Intolerant Polycythemia Vera Terminated USA | ITA | CAN | AUS 0
NCT03669965 Phase II Ruxolitinib KRT-232 KRT-232 Compared to Ruxolitinib in Patients With Phlebotomy-Dependent Polycythemia Vera Unknown status USA | POL | HUN | FRA | ESP | DEU 0
NCT03862157 Phase Ib/II Azacitidine + MLN4924 + Venetoclax Azacitidine, Venetoclax, and Pevonedistat in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Active, not recruiting USA 0
NCT04041050 Phase I Navitoclax Navitoclax + Ruxolitinib A Study Evaluating Safety and Tolerability, and Pharmacokinetics of Navitoclax Alone and in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasm Active, not recruiting USA | TUR | SWE | ITA | HRV | GBR | FRA | ESP | DEU | BGR | BEL 3
NCT04116502 Phase III Ruxolitinib Hydroxyurea Alpha 2 Interferon MITHRIDATE: Ruxolitinib Versus Hydroxycarbamide or Interferon as First Line Therapy in High Risk Polycythemia Vera (MITHRIDATE) Recruiting GBR 0
NCT04262141 Phase II IMG-7289 IMG-7289 in Patients With Essential Thrombocythemia (ET) or Polycythemia Vera (PV) Active, not recruiting USA 0
NCT04282187 Phase II Decitabine + Fedratinib Decitabine + Ruxolitinib Decitabine With Ruxolitinib or Fedratinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms Recruiting USA 0
NCT04644211 Phase II Ruxolitinib Ruxolitinib in Thrombocythemia and Polycythemia Vera Recruiting USA 0
NCT04955938 Phase I Enasidenib + Fedratinib Fedratinib + Ivosidenib A Study of Fedratinib With IDH Inhibition in Advanced-Phase, IDH-Mutated Ph-Negative Myeloproliferative Neoplasms Withdrawn USA 0
NCT05127174 Phase Ib/II Fedratinib Maintenance Fedratinib to Prevent Post-Transplant Relapse in Myeloproliferative Neoplasms Active, not recruiting USA 0
NCT05481151 Phase III Ropeginterferon A Study to Assess Efficacy, Safety, and Tolerability of P1101 in Adult Patients With PV Active, not recruiting USA | CAN 0
NCT05558696 Phase II IMG-7289 Bomedemstat in Patients With Polycythemia Vera Active, not recruiting USA | GBR | AUS 0
NCT06093672 Phase III Givinostat Hydroxyurea Study on Efficacy and Safety of Givinostat Versus Hydroxyurea in Patients With Polycythemia Vera (GIV-IN PV) Recruiting USA | POL | NLD | ITA | ISR | IRL | HUN | HRV | GBR | FRA | ESP | DEU | BGR | AUT 1
NCT06218628 Phase I Pacritinib + Talazoparib Pacritinib w/ Talazoparib in Pts w/ Myeloproliferative Neoplasms Unresponsive to JAK2 Inhibition Recruiting USA 0
NCT06291987 Phase I Ivosidenib + Ruxolitinib Ivosidenib and Ruxolitinib in Patients With Advanced Myeloproliferative Neoplasms (MPNs) That Have an IDH1 Gene Mutation (MPN) Recruiting USA 0
NCT06343805 Phase I AJ1-11095 A Phase 1 Study of AJ1-11095 in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed by a Type I JAK2 Inhibitor (JAK2i) Recruiting USA 0
NCT06351631 Phase III IMG-7289 A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017) Recruiting USA | NZL | ITA | GBR | AUS 1