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Molecular Profile | ATM R2832C |
Therapy | Niraparib + RP-3500 |
Indication/Tumor Type | mantle cell lymphoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ATM R2832C | mantle cell lymphoma | sensitive | Niraparib + RP-3500 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, the combination of RP-3500 with Zejula (niraparib) inhibited tumor growth in a mantle cell lymphoma cell line xenograft model harboring ATM R2832C (PMID: 34911817). | 34911817 |
PubMed Id | Reference Title | Details |
---|---|---|
(34911817) | RP-3500: A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors. | Full reference... |