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Profile Name | ATM R2832C |
Gene Variant Detail | |
Relevant Treatment Approaches | Olaparib |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
ATM R2832C | mantle cell lymphoma | sensitive | RP-3500 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, RP-3500 inhibited viability in a mantle cell lymphoma cell line harboring ATM R2832C in culture, and inhibited tumor growth in a cell line xenograft model (PMID: 34911817). | 34911817 | |
ATM R2832C | mantle cell lymphoma | sensitive | Niraparib + RP-3500 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, the combination of RP-3500 with Zejula (niraparib) inhibited tumor growth in a mantle cell lymphoma cell line xenograft model harboring ATM R2832C (PMID: 34911817). | 34911817 |