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| Molecular Profile | ATM V2288fs |
| Therapy | Olaparib |
| Indication/Tumor Type | prostate cancer |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ATM V2288fs | prostate cancer | predicted - sensitive | Olaparib | Case Reports/Case Series | Actionable | In a Phase II trial (TOPARP-A), Lynparza (olaparib) treatment resulted in a conversion in the circulating tumor-cell count, a 29% decrease in PSA level, and radiologic stable disease in a patient with metastatic castration-resistant prostate cancer harboring ATM V2288fs (PMID: 26510020; NCT01682772). | 26510020 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26510020) | DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer. | Full reference... |