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Molecular Profile | KIT exon11 KIT exon13 |
Therapy | DCC-3009 |
Indication/Tumor Type | gastrointestinal stromal tumor |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT exon11 KIT exon13 | gastrointestinal stromal tumor | predicted - sensitive | DCC-3009 | Preclinical | Actionable | In a preclinical study, DCC-3009 induced tumor regression in a xenograft model of gastrointestinal stromal tumor harboring KIT exon 11 and exon 13 mutations (Cancer Res (2023) 83 (7_Supplement): 4033). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
Abstract 4033: Pan-exon mutant KIT inhibitor DCC-3009 demonstrates tumor regressions in preclinical gastrointestinal stromal tumor models | Full reference... |