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Molecular Profile | RAD51D K91fs |
Therapy | Olaparib |
Indication/Tumor Type | triple-receptor negative breast cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
RAD51D K91fs | triple-receptor negative breast cancer | sensitive | Olaparib | Preclinical - Cell culture | Actionable | In a preclinical study, Lynparza (olaparib) treatment inhibited viability of triple-negative breast cancer cells expressing RAD51D K91fs in culture (PMID: 33151324). | 33151324 |
PubMed Id | Reference Title | Details |
---|---|---|
(33151324) | Molecular Features and Functional Implications of Germline Variants in Triple-Negative Breast Cancer. | Full reference... |