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Molecular Profile | SMARCA4 del |
Therapy | SMD-3040 |
Indication/Tumor Type | melanoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
SMARCA4 del | melanoma | sensitive | SMD-3040 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, SMD-3040 inhibited proliferation of a melanoma cell line with SMARCA4 deletion in culture, and inhibited tumor growth in a cell line xenograft model (PMID: 37523716). | 37523716 |
PubMed Id | Reference Title | Details |
---|---|---|
(37523716) | Discovery of SMD-3040 as a Potent and Selective SMARCA2 PROTAC Degrader with Strong in vivo Antitumor Activity. | Full reference... |