Therapy Detail
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| Therapy Name | SMD-3040 |
| Synonyms | |
| Therapy Description |
SMD-3040 is a proteolysis-targeted chimera (PROTAC) that binds to SMARCA2 and targets it for degradation, potentially inhibiting cell proliferation and growth of SMARCA4-deficient tumors (PMID: 37523716). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| SMD-3040 | SMD3040|SMD 3040 | SMD-3040 is a proteolysis-targeted chimera (PROTAC) that binds to SMARCA2 and targets it for degradation, potentially inhibiting cell proliferation and growth of SMARCA4-deficient tumors (PMID: 37523716). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| SMARCA4 del | lung non-small cell carcinoma | sensitive | SMD-3040 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, SMD-3040 inhibited proliferation of a non-small cell lung cancer cell line with SMARCA4 deletion in culture, and inhibited tumor growth in a cell line xenograft model (PMID: 37523716). | 37523716 |
| SMARCA4 del | melanoma | sensitive | SMD-3040 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, SMD-3040 inhibited proliferation of a melanoma cell line with SMARCA4 deletion in culture, and inhibited tumor growth in a cell line xenograft model (PMID: 37523716). | 37523716 |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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