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Molecular Profile BTK L528W
Therapy Tirabrutinib
Indication/Tumor Type chronic lymphocytic leukemia
Response Type predicted - resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BTK L528W chronic lymphocytic leukemia predicted - resistant Tirabrutinib Case Reports/Case Series Actionable In Phase I trials, two patients with chronic lymphocytic leukemia progressed on treatment with Tirabrutinib (ONO-4059) and each were subsequently found to have acquired BTK L528W (PMID: 37257190; NCT01659255 and NCT02457598). 37257190
PubMed Id Reference Title Details
(37257190) BTK mutations in patients with chronic lymphocytic leukemia receiving tirabrutinib. Full reference...