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Therapy Name Tirabrutinib
Synonyms
Therapy Description

Tirabrutinib (ONO-4059) is a selective inhibitor of BTK, which potentially induces antibody-dependent cell-mediated cytotoxicity against tumor cells and inhibits tumor growth (PMID: 27684575, PMID: 27776353, PMID: 32583848).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Tirabrutinib ONO-GS-4059|ONO-WG-307|ONO-4059|GS 4059|GS4059 BTK inhibitor 38 Tirabrutinib (ONO-4059) is a selective inhibitor of BTK, which potentially induces antibody-dependent cell-mediated cytotoxicity against tumor cells and inhibits tumor growth (PMID: 27684575, PMID: 27776353, PMID: 32583848).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04947319 Phase II Tirabrutinib Study of Tirabrutinib (ONO-4059) in Patients With Primary Central Nervous System Lymphoma (PROSPECT Study) Recruiting USA 0
NCT02457598 Phase I Entospletinib + Tirabrutinib Tirabrutinib Idelalisib + Obinutuzumab + Tirabrutinib Entospletinib + Obinutuzumab + Tirabrutinib Idelalisib + Tirabrutinib Dose Escalation and Dose Expansion Study of Tirabrutinib in Combination With Other Targeted Anti-cancer Therapies in Adults With B-cell Malignancies Terminated USA | GBR | FRA 0


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