Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Molecular Profile | BTK T474I BTK C481S BTK L528W |
| Therapy | Tirabrutinib |
| Indication/Tumor Type | chronic lymphocytic leukemia |
| Response Type | predicted - resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BTK T474I BTK C481S BTK L528W | chronic lymphocytic leukemia | predicted - resistant | Tirabrutinib | Case Reports/Case Series | Actionable | In Phase I trials, a patient with chronic lymphocytic leukemia progressed on treatment with Tirabrutinib (ONO-4059) and was subsequently found to have acquired BTK C481S, L528W, and T474I (PMID: 37257190;NCT01659255 and NCT02457598). | 37257190 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (37257190) | BTK mutations in patients with chronic lymphocytic leukemia receiving tirabrutinib. | Full reference... |