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| Molecular Profile | TP53 mutant |
| Therapy | Obinutuzumab + Venetoclax + Zanubrutinib |
| Indication/Tumor Type | mantle cell lymphoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 mutant | mantle cell lymphoma | sensitive | Obinutuzumab + Venetoclax + Zanubrutinib | Guideline | Actionable | The combination of Brukinsa (zanubrutinib), Gazyva (obinutuzumab), and Venclexta (venetoclax) is included in guidelines as induction therapy for patients with mantle cell lymphoma harboring a TP53 mutation (NCCN.org). | detail... |
| PubMed Id | Reference Title | Details |
|---|---|---|
| NCCN.org | Full reference... |