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| Molecular Profile | TP53 loss |
| Therapy | SP600125 |
| Indication/Tumor Type | colon carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 loss | colon carcinoma | sensitive | SP600125 | Preclinical | Actionable | In a preclinical study, SP600125 induced cell death in colon carcinoma cells deficient for p53 (PMID: 22438244). | 22438244 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (22438244) | Selective killing of p53-deficient cancer cells by SP600125. | Full reference... |