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| Molecular Profile | KIT D820V |
| Therapy | Nilotinib |
| Indication/Tumor Type | mucosal melanoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT D820V | mucosal melanoma | predicted - sensitive | Nilotinib | Case Reports/Case Series | Actionable | In a Phase II trial (NICAM), Tasigna (nilotinib) treatment demonstrated activity in patients with acral (n=6) or mucosal melanoma (n=20) harboring KIT mutations, resulting in an objective response rate at 12 weeks of 19% (5/26), including a mucosal melanoma patient harboring KIT D820V, who had a 38.1% reduction of target lesions, remained on treatment for 54.2 months, with a progression-free survival of 15.6 months, and overall survival of 63.7 months (PMID: 38417447). | 38417447 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (38417447) | Nilotinib in KIT-driven advanced melanoma: Results from the phase II single-arm NICAM trial. | Full reference... |