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| Molecular Profile | TP53 Y163C |
| Therapy | APR-246 + Cisplatin |
| Indication/Tumor Type | lung small cell carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 Y163C | lung small cell carcinoma | sensitive | APR-246 + Cisplatin | Preclinical | Actionable | In a preclinical study, the combination of APR-246 and Platinol (cisplatin) worked synergistically to inhibit growth of small lung cancer cells harboring TP53 Y163C in culture (PMID: 26086967). | 26086967 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26086967) | APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells. | Full reference... |