Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Molecular Profile | BRAF F516G BRAF V600E |
| Therapy | U0126 |
| Indication/Tumor Type | melanoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF F516G BRAF V600E | melanoma | sensitive | U0126 | Preclinical - Cell culture | Actionable | In a preclinical study, U0126 inhibited Erk phosphorylation and downstream signaling and viability in a melanoma cell line harboring BRAF V600E and expressing BRAF F516G in culture (PMID: 24112705). | 24112705 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (24112705) | Resistance to vemurafenib resulting from a novel mutation in the BRAFV600E kinase domain. | Full reference... |