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Therapy Name	U0126
Synonyms
Therapy Description	U0126 binds and inhibits Mek1 and Mek2, which may inhibit the activation of downstream signaling targets and reduce tumor cell proliferation (PMID: 9873633).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
U0126			MEK inhibitor (Pan) 27 MEK1 Inhibitor 27 MEK2 Inhibitor 25	U0126 binds and inhibits Mek1 and Mek2, which may inhibit the activation of downstream signaling targets and reduce tumor cell proliferation (PMID: 9873633).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
BRAF D594G	melanoma	resistant	U0126	Preclinical - Cell culture	Actionable	In a preclinical study, melanoma cells harboring BRAF D594G demonstrated resistance to U0126 treatment in culture (PMID: 18794803).	18794803
BRAF G469E	melanoma	resistant	U0126	Preclinical - Cell culture	Actionable	In a preclinical study, melanoma cells harboring BRAF G469E demonstrated resistance to U0126 treatment in culture (PMID: 18794803).	18794803
BRAF K601E	melanoma	predicted - sensitive	U0126	Preclinical - Cell culture	Actionable	In a preclinical study, U0126 treatment inhibited growth of melanoma cells harboring BRAF K601E in culture (PMID: 18794803).	18794803
BRAF V600E	melanoma	predicted - sensitive	U0126	Preclinical - Cell culture	Actionable	In a preclinical study, U0126 treatment inhibited Erk phosphorylation and reduced growth of melanoma cells harboring BRAF V600E in culture (PMID: 18794803).	18794803
MAP2K1 L98_K104delinsQ	Advanced Solid Tumor	resistant	U0126	Preclinical - Cell culture	Actionable	In a preclinical study, U0126 treatment failed to inhibit activation of Mek and Erk in human cells expressing MAP2K1 L98_K104delinsQ in culture (PMID: 29768711).	29768711
FGFR3 over exp	glioblastoma	sensitive	U0126	Preclinical	Actionable	In a preclinical study, U0126 inhibited downstream signaling and growth of glioblastoma cells over-expressing Fgfr3 in culture (PMID: 23298836).	23298836

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