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| Profile Name | BRAF F516G BRAF V600E |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| BRAF F516G BRAF V600E | melanoma | resistant | PLX4720 | Preclinical - Cell culture | Actionable | In a preclinical study, a melanoma cell line harboring BRAF V600E and expressing F516G was resistant to PLX4720 in culture (PMID: 24112705). | 24112705 | |
| BRAF F516G BRAF V600E | melanoma | sensitive | U0126 | Preclinical - Cell culture | Actionable | In a preclinical study, U0126 inhibited Erk phosphorylation and downstream signaling and viability in a melanoma cell line harboring BRAF V600E and expressing BRAF F516G in culture (PMID: 24112705). | 24112705 |