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| Molecular Profile | KIT G565_P573del KIT Y823D |
| Therapy | Imatinib |
| Indication/Tumor Type | gastrointestinal stromal tumor |
| Response Type | predicted - resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT G565_P573del KIT Y823D | gastrointestinal stromal tumor | predicted - resistant | Imatinib | Case Reports/Case Series | Actionable | In a clinical study, KIT Y823D was identified as a secondary mutation in a patient with gastrointestinal stromal tumor harboring a primary KIT G565_P573del mutation who developed resistance to Gleevec (imatinib) (PMID: 21475850). | 21475850 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (21475850) | Secondary resistance to imatinib in patients with gastrointestinal stromal tumors through an acquired KIT exon 17 mutation. | Full reference... |