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| Molecular Profile | PTEN inact mut |
| Therapy | Aspirin |
| Indication/Tumor Type | rectum cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PTEN inact mut | rectum cancer | sensitive | Aspirin | Guideline | Actionable | Aspirin is included in guidelines as adjuvant therapy (category 2A) for patients with advanced rectal cancer harboring inactivating PTEN mutations, including deep deletions, and other somatic mutations affecting the PI3K pathway genes PIK3CA or PIK3R1 (NCCN.org). | detail... |
| PubMed Id | Reference Title | Details |
|---|---|---|
| NCCN.org | Full reference... |