Therapy Detail
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| Therapy Name | Aspirin |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Aspirin | Durlaza | Acetylsalicylic acid |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PTEN del | rectum cancer | sensitive | Aspirin | Guideline | Actionable | Aspirin is included in guidelines as adjuvant therapy (category 2A) for patients with advanced rectal cancer harboring deep PTEN deletions and other somatic mutations affecting the PI3K pathway genes PIK3CA, PIK3R1, or PTEN (NCCN.org). | detail... |
| PTEN inact mut | rectum cancer | sensitive | Aspirin | Guideline | Actionable | Aspirin is included in guidelines as adjuvant therapy (category 2A) for patients with advanced rectal cancer harboring inactivating PTEN mutations, including deep deletions, and other somatic mutations affecting the PI3K pathway genes PIK3CA or PIK3R1 (NCCN.org). | detail... |
| PTEN inact mut | colon cancer | sensitive | Aspirin | Guideline | Actionable | Aspirin is included in guidelines as adjuvant therapy (category 2A) for patients with advanced colon cancer harboring inactivating PTEN mutations, including deep deletions, and other somatic mutations affecting the PI3K pathway genes PIK3CA or PIK3R1 (NCCN.org). | detail... |
| PTEN del | colon cancer | sensitive | Aspirin | Guideline | Actionable | Aspirin is included in guidelines as adjuvant therapy (category 2A) for patients with advanced colon cancer harboring deep PTEN deletions and other somatic mutations affecting the PI3K pathway genes PIK3CA, PIK3R1, or PTEN (NCCN.org). | detail... |
| PIK3CA exon10 | colon cancer | sensitive | Aspirin | Guideline | Actionable | Aspirin is included in guidelines as adjuvant therapy (category 2A) for patients with advanced colon cancer harboring PIK3CA exon 10 (reported as exon 9) mutations, including hotspot mutations occurring at E542, E545, and Q546, and other somatic mutations affecting the PI3K pathway genes PIK3CA, PIK3R1, or PTEN (NCCN.org). | detail... |
| PIK3CA exon21 | colon cancer | sensitive | Aspirin | Guideline | Actionable | Aspirin is included in guidelines as adjuvant therapy (category 2A) for patients with advanced colon cancer harboring PIK3CA exon 21 (reported as exon 20) mutations, including hotspot mutations occurring at Y1021, M1043, N1044, and H1047, and other somatic mutations affecting the PI3K pathway genes PIK3CA, PIK3R1, or PTEN (NCCN.org). | detail... |
| PIK3CA inact mut | rectum cancer | sensitive | Aspirin | Guideline | Actionable | Aspirin is included in guidelines as adjuvant therapy (category 2A) for patients with advanced rectal cancer harboring PIK3CA mutations, including hotspot mutations in exon 10 (reported as exon 9) and exon 21 (reported as exon 20), and other somatic mutations affecting the PI3K pathway genes PIK3R1 or PTEN (NCCN.org). | detail... |
| PIK3CA exon10 | rectum cancer | sensitive | Aspirin | Guideline | Actionable | Aspirin is included in guidelines as adjuvant therapy (category 2A) for patients with advanced rectal cancer harboring PIK3CA exon 10 (reported as exon 9) mutations, including hotspot mutations occurring at E542, E545, and Q546, and other somatic mutations affecting the PI3K pathway genes PIK3CA, PIK3R1, or PTEN (NCCN.org). | detail... |
| PIK3CA exon21 | rectum cancer | sensitive | Aspirin | Guideline | Actionable | Aspirin is included in guidelines as adjuvant therapy (category 2A) for patients with advanced rectal cancer harboring PIK3CA exon 21 (reported as exon 20) mutations, including hotspot mutations occurring at Y1021, M1043, N1044, and H1047, and other somatic mutations affecting the PI3K pathway genes PIK3CA, PIK3R1, or PTEN (NCCN.org). | detail... |
| PIK3CA act mut | colon cancer | sensitive | Aspirin | Guideline | Actionable | Aspirin is included in guidelines as adjuvant therapy (category 2A) for patients with advanced colon cancer harboring PIK3CA mutations, including hotspot mutations in exon 10 (reported as exon 9) and exon 21 (reported as exon 20), and other somatic mutations affecting the PI3K pathway genes PIK3R1 or PTEN (NCCN.org). | detail... |
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03819101 | Phase III | Atorvastatin Aspirin + Atorvastatin Aspirin | Trial of Acetylsalicylic Acid and Atorvastatin in Patients With Castrate-resistant Prostate Cancer (PEACE-4) | Recruiting | SVK | ITA | FRA | CZE | CHE | 1 |
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