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| Molecular Profile | KIT M552_K558del |
| Therapy | Ponatinib |
| Indication/Tumor Type | gastrointestinal stromal tumor |
| Response Type | predicted - resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT M552_K558del | gastrointestinal stromal tumor | predicted - resistant | Ponatinib | Case Reports/Case Series | Actionable | In a clinical study, a GIST patient harboring KIT M552_K558del, resistant to multiple tyrosine kinase inhibitors, demonstrated resistance to Iclusig (ponatinib) treatment as indicated by disease progression after 4 weeks of treatment (PMID: 25239608). | 25239608 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (25239608) | Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients. | Full reference... |