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| Molecular Profile | KIT V560_Y578del |
| Therapy | Imatinib + Infigratinib |
| Indication/Tumor Type | gastrointestinal stromal tumor |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT V560_Y578del | gastrointestinal stromal tumor | sensitive | Imatinib + Infigratinib | Preclinical - Cell culture | Actionable | In a preclinical study, Truseltiq (infigratinib) and Gleevec (imatinib) combination treatment demonstrated enhanced antiproliferative activity in gastrointestinal stromal tumor cells harboring KIT V560_Y578del in culture (PMID: 25673643). | 25673643 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (25673643) | FGFR-Mediated Reactivation of MAPK Signaling Attenuates Antitumor Effects of Imatinib in Gastrointestinal Stromal Tumors. | Full reference... |