Reference Detail

Ref Type

PMID

Authors

M Swaminathan, HM. Kantarjian, N Daver, G Borthakur, M Ohanian, T Kadia, CD. DiNardo, N Jain, Z Estrov, A Ferrajoli, G Garcia-Manero, M Konopleva, M Andreeff, N Pemmaraju, EJ. Jabbour, WG Wierda, F Ravandi, MR Pinsoy and JE. Cortes

Title

The Combination of Quizartinib with Azacitidine or Low Dose Cytarabine Is Highly Active in Patients (Pts) with FLT3-ITD Mutated Myeloid Leukemias: Interim Report of a Phase I/II Trial

Journal	Vol	Issue	Date	Pages	Journal Short Title

URL

https://ash.confex.com/ash/2017/webprogram/Paper107890.html

Abstract Text

ASH 59th Annual Meeting and Exposition, Dec 2017, Abstract 723

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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Gene	Variant	Impact	Protein Effect	Variant Description	Associated with drug Resistance
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
FLT3 exon 14 ins	acute myeloid leukemia	sensitive	Cytarabine + Quizartinib	Phase Ib/II	Actionable	In a Phase I/II trial, Vanflyta (quizartinib) in combination with Cytosar-U (cytarabine) resulted in a median overall survival of 6.7 months and a median progression-free survival of 3 months in acute myeloid leukemia patients harboring FLT3 ITD mutations (ASH 59th Annual Meeting and Exposition, Dec 2017, Abstract 723).	detail...
FLT3 exon 14 ins	acute myeloid leukemia	predicted - sensitive	Azacitidine + Quizartinib	Phase Ib/II	Actionable	In a Phase I/II trial, Vanflyta (quizartinib) in combination with Vidaza (azacitidine) resulted in a median overall survival of 13.4 months and a median progression-free survival of 6.9 months in acute myeloid leukemia patients harboring FLT3 ITD mutations (ASH 59th Annual Meeting and Exposition, Dec 2017, Abstract 723).	detail...

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