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Authors | Rami Rahal, Michelle Maynard, Wei Hu, Jason Brubaker, Qiongfang Cao, Joseph L. Kim, Michael P. Sheets, Douglas P. Wilson, Kevin J. Wilson, Lucian DiPietro, Paul Fleming, Timothy P. LaBranche, Beni Wolf, Timothy Guzi, Christoph Lengauer and Erica K. Evans | ||||||||||||
Title | BLU-667 is a potent and highly selective RET inhibitor being developed for RET-driven cancers | ||||||||||||
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URL | http://mct.aacrjournals.org/content/17/1_Supplement/B151 | ||||||||||||
Abstract Text | Mol Cancer Ther 2018;17(1 Suppl):Abstract nr B151 |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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RET C634W | medullary thyroid carcinoma | sensitive | Pralsetinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Gavreto (pralsetinib) inhibited Ret signaling and proliferation of a medullary thyroid cancer cell line harboring RET C634W in culture, and inhibited tumor growth in xenograft models (PMID: 29657135). | detail... 29657135 |