Reference Detail

Ref Type

PMID

Authors

Rami Rahal, Michelle Maynard, Wei Hu, Jason Brubaker, Qiongfang Cao, Joseph L. Kim, Michael P. Sheets, Douglas P. Wilson, Kevin J. Wilson, Lucian DiPietro, Paul Fleming, Timothy P. LaBranche, Beni Wolf, Timothy Guzi, Christoph Lengauer and Erica K. Evans

Title

BLU-667 is a potent and highly selective RET inhibitor being developed for RET-driven cancers

Journal	Vol	Issue	Date	Pages	Journal Short Title
Mol Cancer Ther

URL

http://mct.aacrjournals.org/content/17/1_Supplement/B151

Abstract Text

Mol Cancer Ther 2018;17(1 Suppl):Abstract nr B151

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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Gene	Variant	Impact	Protein Effect	Variant Description	Associated with drug Resistance
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
RET C634W	medullary thyroid carcinoma	sensitive	Pralsetinib	Preclinical - Cell line xenograft	Actionable	In a preclinical study, Gavreto (pralsetinib) inhibited Ret signaling and proliferation of a medullary thyroid cancer cell line harboring RET C634W in culture, and inhibited tumor growth in xenograft models (PMID: 29657135).	detail... 29657135

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