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Ref Type
PMID
Authors J Trent, A Wagner, W Tap, A Shields, A Patnaik, G Tinoco, G Michelson, E Martin, O Alcantar, M Pelayo, C Zhang, B West, P Severson
Title A PHASE 1 PHARMACOKINETIC (PK) AND PHARMACODYNAMIC (PD) STUDY OF PLX9486, ANOVEL KIT INHIBITOR WITH POTENT ACTIVITY AGAINST EXON 17/18 ACTIVATION LOOP MUTATIONS IN PATIENTS WITH GASTROINTESTINAL STROMAL TUMOR (GIST)
Journal Vol Issue Date Pages Journal Short Title
CTOS Annual Meeting, Nov 2017, abstract # 2771952 Nov 2017
URL https://www.ctos.org/Portals/0/PDF/2017%20CTOS%20Final%20Program.pdf
Abstract Text CTOS Annual Meeting, Nov 2017, abstract # 2771952 http://gistsupport.org/posters/CTOS_PLX121.pdf

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT exon11 KIT exon17 gastrointestinal stromal tumor predicted - sensitive PLX9486 Phase I Actionable In a Phase I trial, PLX9486 treatment resulted in partial response with 33% decrease of tumor size after 4 cycles of therapy in a patient with gastrointestinal stromal tumor harboring a primary KIT exon 11 mutation and a secondary KIT exon 17 mutation, who progressed on prior Gleevec (imatinib mesylate) and Sutent (sunitinib) therapies (CTOS Annual Meeting, Nov 2017, abstract # 2771952). detail...