Reference Detail

Ref Type

PMID

Authors

J Trent, A Wagner, W Tap, A Shields, A Patnaik, G Tinoco, G Michelson, E Martin, O Alcantar, M Pelayo, C Zhang, B West, P Severson

Title

A PHASE 1 PHARMACOKINETIC (PK) AND PHARMACODYNAMIC (PD) STUDY OF PLX9486, ANOVEL KIT INHIBITOR WITH POTENT ACTIVITY AGAINST EXON 17/18 ACTIVATION LOOP MUTATIONS IN PATIENTS WITH GASTROINTESTINAL STROMAL TUMOR (GIST)

Journal	Vol	Issue	Date	Pages	Journal Short Title
CTOS Annual Meeting, Nov 2017, abstract # 2771952			Nov 2017

URL

https://www.ctos.org/Portals/0/PDF/2017%20CTOS%20Final%20Program.pdf

Abstract Text

CTOS Annual Meeting, Nov 2017, abstract # 2771952 http://gistsupport.org/posters/CTOS_PLX121.pdf

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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
KIT exon11 KIT exon17	gastrointestinal stromal tumor	predicted - sensitive	PLX9486	Phase I	Actionable	In a Phase I trial, PLX9486 treatment resulted in partial response with 33% decrease of tumor size after 4 cycles of therapy in a patient with gastrointestinal stromal tumor harboring a primary KIT exon 11 mutation and a secondary KIT exon 17 mutation, who progressed on prior Gleevec (imatinib mesylate) and Sutent (sunitinib) therapies (CTOS Annual Meeting, Nov 2017, abstract # 2771952).	detail...

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