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Reference Detail

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Ref Type
PMID
Authors M von Mehren; RL. Jones; S Bauer; YK Kang; P Schöffski; F Eskens; C Serrano; P Cassier; O Mir; WD. Tap; P Rutkowski; J Trent; S Patel; SP. Chawla; T Zhou; T Lauz; O Schmidt-Kittler; KK. Mamlouk; BB. Wolf; S George
Title AVAPRITINIB IS HIGHLY ACTIVE AND WELL-TOLERATED IN PATIENTS (PTS) WITH ADVANCED GIST DRIVEN BY DIVERSE VARIETY OF ONCOGENIC MUTATIONS IN KIT AND PDGFRA
Journal Vol Issue Date Pages Journal Short Title
URL https://www.ctos.org/Portals/0/PDF/2018%20CTOS%20Final%20Program.pdf
Abstract Text The CTOS 2018 Annual Meeting, Nov 14-17, Rome Italy, Paper 012 3027631

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT mutant gastrointestinal stromal tumor predicted - sensitive Avapritinib Phase I Actionable In a Phase I (NAVIGATOR) trial, Ayvakit (avapritinib) treatment resulted in an objective response rate of 13% (7/52, 7 partial responses) and a disease control rate of 63% (33/52) in patients with KIT-mutant gastrointestinal stromal tumor (The CTOS 2018 Annual Meeting, Nov 14-17, Rome Italy, Paper 012 3027631; NCT02508532). detail...