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Ref Type

Journal Article

PMID

(30559058)

Authors

Mori S, Patel RD, Ahmad S, Varela J, Smith T, Altoos R, Shen Q, Goldstein SC, Persky DO

Title

Aggressive Leukemic Non-Nodal Mantle Cell Lymphoma With P53 Gene Rearrangement/Mutation is Highly Responsive to Rituximab/Ibrutinib Combination Therapy.

Journal	Vol	Issue	Date	Pages	Journal Short Title
Clinical lymphoma, myeloma & leukemia	19	2	2019 Feb	e93-e97	Clin Lymphoma Myeloma Leuk

URL

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
TP53 G244S	mantle cell lymphoma	predicted - sensitive	Ibrutinib + Rituximab	Case Reports/Case Series	Actionable	In a clinical case study, a patient with non-nodal leukemic mantle cell lymphoma harboring TP53 G244S, as well as KMT2A V2593A and BCOR S830Cfs*6, achieved complete remission (CR) with no evident minimum residual disease after 5 months of combined Rituxan (rituximab) and Imbruvica (ibrutinib) therapy, and following subsequent autologous stem-cell transplantation remained in CR beyond 18 months (PMID: 30559058).	30559058
TP53 loss	mantle cell lymphoma	no benefit	Bendamustine + Rituximab	Case Reports/Case Series	Actionable	In a clinical case study, a patient with non-nodal leukemic mantle cell lymphoma with TP53 loss, as well as a CCND1 translocation, had no response to combined Rituxan (rituximab) and Treanda (bendamustine) therapy, and had a doubling of white blood cells during two cycles of treatment (PMID: 30559058).	30559058
TP53 loss	mantle cell lymphoma	predicted - sensitive	Ibrutinib + Rituximab	Case Reports/Case Series	Actionable	In a clinical case study, a patient with non-nodal leukemic mantle cell lymphoma with TP53 loss, as well as a CCND1 translocation, had a rapid response to combined Rituxan (rituximab) and Imbruvica (ibrutinib) therapy, achieved a complete remission (CR) within 6 months, underwent autologous stem-cell transplantation, and remained in CR 18 months thereafter (PMID: 30559058).	30559058

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