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Ref Type Journal Article
PMID (24359404)
Authors Heldin CH
Title Targeting the PDGF signaling pathway in tumor treatment.
URL
Abstract Text Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important functions in the regulation of growth and survival of certain cell types during embryonal development and e.g. tissue repair in the adult. Overactivity of PDGF receptor signaling, by overexpression or mutational events, may drive tumor cell growth. In addition, pericytes of the vasculature and fibroblasts and myofibroblasts of the stroma of solid tumors express PDGF receptors, and PDGF stimulation of such cells promotes tumorigenesis. Inhibition of PDGF receptor signaling has proven to useful for the treatment of patients with certain rare tumors. Whether treatment with PDGF/PDGF receptor antagonists will be beneficial for more common malignancies is the subject for ongoing studies.

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Molecular Profile Treatment Approach
PDGFRB R849_K860delinsHAGLELHLQ PDGFR Inhibitor (Pan)
PDGFRB D850V PDGFR Inhibitor (Pan)
PDGFRB Y562_R565del PDGFR Inhibitor (Pan)
PDGFRB Y562C PDGFR-beta Inhibitor
PDGFRB R561C PDGFR Inhibitor (Pan)
PDGFRB I535_A540delinsVPSWP PDGFR-beta Inhibitor
PDGFRB I535_A540delinsVPSWP PDGFR Inhibitor (Pan)
PDGFRB over exp PDGFR-beta Inhibitor
PDGFRB act mut PDGFR-beta Inhibitor
PDGFRB N666K PDGFR-beta Inhibitor
PDGFRB R561C PDGFR-beta Inhibitor
PDGFRB W566_V568delinsL PDGFR-beta Inhibitor
PDGFRB Y562_R565del PDGFR-beta Inhibitor
PDGFRB amp PDGFR Inhibitor (Pan)
PDGFRB Y562_V572dup PDGFR Inhibitor (Pan)
PDGFRB I538_L539insR PDGFR Inhibitor (Pan)
PDGFRB R849_K860delinsHAGLELHLQ PDGFR-beta Inhibitor
PDGFRB P584R PDGFR-beta Inhibitor
PDGFRB R849_D850delinsH PDGFR Inhibitor (Pan)
PDGFRB T681M PDGFR Inhibitor (Pan)
PDGFRB W566_V568delinsL PDGFR Inhibitor (Pan)
PDGFRB A537_I538delinsDN PDGFR Inhibitor (Pan)
PDGFRB D850V PDGFR-beta Inhibitor
PDGFRB N666K PDGFR Inhibitor (Pan)
PDGFRB D850Y PDGFR-beta Inhibitor
PDGFRB amp PDGFR-beta Inhibitor
PDGFRB act mut PDGFR Inhibitor (Pan)
PDGFRB A537_I538delinsDN PDGFR-beta Inhibitor
PDGFRB T681M PDGFR-beta Inhibitor
PDGFRB Y562_V572dup PDGFR-beta Inhibitor
PDGFRB R561_Y562delinsH PDGFR-beta Inhibitor
PDGFRB R561_Y562delinsH PDGFR Inhibitor (Pan)
PDGFRB over exp PDGFR Inhibitor (Pan)
PDGFRB T681I PDGFR-beta Inhibitor
PDGFRB D850Y PDGFR Inhibitor (Pan)
PDGFRB T681I PDGFR Inhibitor (Pan)
PDGFRB E563_I564del PDGFR Inhibitor (Pan)
PDGFRB D850N PDGFR-beta Inhibitor
PDGFRB P584R PDGFR Inhibitor (Pan)
PDGFRB Y562C PDGFR Inhibitor (Pan)
PDGFRB I538_L539insR PDGFR-beta Inhibitor
PDGFRB N666H PDGFR Inhibitor (Pan)
PDGFRB E563_I564del PDGFR-beta Inhibitor
PDGFRB N666H PDGFR-beta Inhibitor
PDGFRB R849_D850delinsH PDGFR-beta Inhibitor
PDGFRB D850N PDGFR Inhibitor (Pan)
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References