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Ref Type

PMID

(33154983)

Authors

Andreev-Drakhlin A, Cabanillas M, Amini B, Subbiah V

Title

Systemic and CNS Activity of Selective RET Inhibition With Selpercatinib (LOXO-292) in a Patient With RET-Mutant Medullary Thyroid Cancer With Extensive CNS Metastases.

Journal	Vol	Issue	Date	Pages	Journal Short Title
JCO precision oncology	4		2020		JCO Precis Oncol

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Abstract Text

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
RET M918T	medullary thyroid carcinoma	sensitive	Cabozantinib	Case Reports/Case Series	Actionable	In a clinical case study, Cometriq (cabozantinib) treatment resulted in a partial response in a patient with medullary thyroid carcinoma with extensive CNS metastasis harboring RET M918T, although the patient experienced multiple adverse effects and her disease progressed after 8 months of treatment (PMID: 33154983).	33154983
RET M918T	medullary thyroid carcinoma	sensitive	Selpercatinib	Case Reports/Case Series	Actionable	In a clinical case study, Retevmo (selpercatinib) treatment resulted in rapid clinical improvement and complete resolution of the brain metastasis in a patient with metastatic medullary thyroid carcinoma harboring RET M918T whose disease progressed on prior Cometriq (cabozantinib) treatment, an official partial extracranial response was achieved at 1 year of treatment, until disease progression at 17 months (PMID: 33154983).	33154983

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