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PMID (33461766)
Authors Venkatesh A, Joshi A, Allinson K, Das T, Santarius T, Jefferies SJ, Harris FP, Jena R, Doherty GJ
Title Response to BRAF and MEK1/2 inhibition in a young adult with BRAF V600E mutant epithelioid glioblastoma multiforme: A Case Report and Literature Review.
Journal Vol Issue Date Pages Journal Short Title
Current problems in cancer 2021 Jan 12 100701 Curr Probl Cancer
URL
Abstract Text Epithelioid glioblastoma multiforme (eGBM) is a rare and aggressive variant of glioblastoma multiforme (GBM) that predominantly affects younger patients and can be difficult to distinguish from other gliomas. Data on how patients with eGBM might be best treated are limited, although genomic analyses have shown that almost half of tumours harbour activating BRAF gene mutations. Here we present the case of a young female with BRAF V600E-mutant eGBM who had a prolonged response to targeted therapy with the BRAF and MEK1/2 inhibitors dabrafenib and trametinib. We review current knowledge about eGBM, including the emerging role for BRAF- ± MEK1/2- targeted therapy.

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