brain glioblastoma multiforme
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ID DOID:3073
Name brain glioblastoma multiforme
Definition A brain glioma that has_material_basis_in abnormally proliferating cells derives_from glial cells, has_symptom seizure, headaches, nausea and vomiting, memory loss, changes to personality, mood or concentration; and localized neurological problems.
Source DiseaseOntology.org
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SNOMEDCT_US_2023_03_01:276828006
Path disease disease of cellular proliferation cancer organ system cancer nervous system cancer central nervous system cancer brain cancer brain glioma brain glioblastoma multiforme

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
CDKN2A loss Milciclib brain glioblastoma multiforme sensitive detail...
BRAF V600E Dabrafenib + Trametinib brain glioblastoma multiforme predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01112527 Phase II Dacomitinib PF-00299804 in Adult Patients With Relapsed/Recurrent Glioblastoma Completed USA 0
NCT01837862 Phase Ib/II Carboplatin + Mebendazole + Temozolomide + Vincristine Sulfate Bevacizumab + Irinotecan + Mebendazole A Phase I/II Study of Mebendazole for the Treatment of Pediatric Gliomas Completed USA 0
NCT01891747 Phase I Bevacizumab + Temozolomide A Phase I Study of High-dose L-methylfolate in Combination With Temozolomide and Bevacizumab in Recurrent High Grade Glioma Completed USA 0
NCT01954576 Phase II NovoTTF Therapy in Treating Patients With Recurrent Glioblastoma Multiforme Terminated USA 0
NCT02052648 Phase Ib/II Temozolomide Indoximod Study of IDO Inhibitor and Temozolomide for Adult Patients With Primary Malignant Brain Tumors Completed USA 0
NCT03522298 Phase II GDC-0084 Safety, Pharmacokinetics and Efficacy of GDC-0084 in Newly-diagnosed Glioblastoma Multiforme Completed USA 0