Reference Detail

Ref Type

PMID

Authors

Thomas Powles, Stephane Oudard, Bernard J. Escudier, Janet Elizabeth Brown, Robert E. Hawkins, Daniel E. Castellano, Alain Ravaud, Michael D. Staehler, Brian I. Rini, Wei Lin, Bridget O'Keeffe, Michelle Byrtek, Mark Lackner, Jill M Spoerke, Joseph A. Ware

Title

A randomized phase II study of GDC-0980 versus everolimus in metastatic renal cell carcinoma (mRCC) patients (pts) after VEGF-targeted therapy (VEGF-TT)

Journal	Vol	Issue	Date	Pages	Journal Short Title

URL

http://meetinglibrary.asco.org/content/132562-144

Abstract Text

J Clin Oncol 32:5s, 2014 (suppl; abstr 4525)

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Molecular Profile	Treatment Approach
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
VHL mutant	renal cell carcinoma	sensitive	Everolimus	Phase I	Actionable	In a Phase I study, Afinitor (everolimus), as compared to Apitolisib (GDC-0980), resulted in a greater progression free survival and overall survival in patients with renal cell carcinoma harboring VHL mutations (J Clin Oncol 32:5s, 2014 (suppl; abstr 4525)).	detail...

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