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Authors | Thomas Powles, Stephane Oudard, Bernard J. Escudier, Janet Elizabeth Brown, Robert E. Hawkins, Daniel E. Castellano, Alain Ravaud, Michael D. Staehler, Brian I. Rini, Wei Lin, Bridget O'Keeffe, Michelle Byrtek, Mark Lackner, Jill M Spoerke, Joseph A. Ware | ||||||||||||
Title | A randomized phase II study of GDC-0980 versus everolimus in metastatic renal cell carcinoma (mRCC) patients (pts) after VEGF-targeted therapy (VEGF-TT) | ||||||||||||
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URL | http://meetinglibrary.asco.org/content/132562-144 | ||||||||||||
Abstract Text | J Clin Oncol 32:5s, 2014 (suppl; abstr 4525) |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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VHL mutant | renal cell carcinoma | sensitive | Everolimus | Phase I | Actionable | In a Phase I study, Afinitor (everolimus), as compared to Apitolisib (GDC-0980), resulted in a greater progression free survival and overall survival in patients with renal cell carcinoma harboring VHL mutations (J Clin Oncol 32:5s, 2014 (suppl; abstr 4525)). | detail... |