Reference Detail

Ref Type

PMID

(36619485)

Authors

Snyder BM, Lion AH, Helvie AE, Marshall MS, Ferguson MJ

Title

Targeted treatment of refractory primitive neuroectodermal tumor arising from an immature teratoma with crizotinib leading to a sustained response.

Journal	Vol	Issue	Date	Pages	Journal Short Title
Clinical case reports	11	1	2023 Jan	e6779	Clin Case Rep

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Abstract Text

Here we present a case of metastatic PNET which arose from an immature teratoma that was refractory to standard Ewing sarcoma chemotherapy. This PNET was determined to have elevated levels of ALK protein via IHC. The patient was treated with crizotinib on a palliative basis with a sustained response.

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
ALK over exp	neuroectodermal tumor	predicted - sensitive	Crizotinib	Case Reports/Case Series	Actionable	In a clinical case study, Xalkori (crizotinib) treatment resulted in reduced volume of several metastatic tumors with disease stability lasting 4 years before treatment discontinuation, and continued for at least another 18 months off therapy, in a pediatric patient with metastatic primitive neuroectodermal tumor with ALK overexpression (PMID: 36619485).	36619485

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