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Ref Type Journal Article
PMID (39224677)
Authors Karasawa H, Yasumizu Y, Kosaka T, Shimoi T, Oya M
Title Efficacy of trametinib in a metastatic urothelial carcinoma patient with a BRAF mutation.
Journal Vol Issue Date Pages Journal Short Title
IJU case reports 7 5 2024 Sep 375-378 IJU Case Rep
URL
Abstract Text BRAF mutations in bladder cancer are rare. MEK inhibitors have excellent clinical benefits in the treatment of melanoma.A 60-year-old male was diagnosed with muscle-invasive bladder cancer and underwent total cystectomy and ileal conduit diversion. Despite 4 cycles of gemcitabine and cisplatin chemotherapy and 3 courses of pembrolizumab, the left obturator lymph node enlarged. Cancer multi-gene panel testing confirmed the BRAF G469A mutation and trametinib was recommended. Three months after the initiation of trametinib (2 mg, qd), the left obturator lymph node shrank by more than 50%. The disease has remained stable for more than 18 months.The present case indicates the potential of trametinib to treat mBUC patients with the BRAF G469A mutation in this setting.

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