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Ref Type Journal Article
PMID (39550033)
Authors Amaral T, Ottaviano M, Arance A, Blank C, Chiarion-Sileni V, Donia M, Dummer R, Garbe C, Gershenwald JE, Gogas H, Guckenberger M, Haanen J, Hamid O, Hauschild A, Höller C, Lebbé C, Lee RJ, Long GV, Lorigan P, Muñoz Couselo E, Nathan P, Robert C, Romano E, Schadendorf D, Sondak V, Suijkerbuijk KPM, van Akkooi ACJ, Michelin O, Ascierto PA, ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Title Cutaneous melanoma: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Journal Vol Issue Date Pages Journal Short Title
Annals of oncology : official journal of the European Society for Medical Oncology 36 1 2025 Jan 10-30 Ann Oncol
URL
Abstract Text

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600X skin melanoma sensitive Cobimetinib + Vemurafenib Guideline Actionable BRAF inhibitor plus MEK inhibitor combination therapy, such as Cotellic (cobimetinib) plus Zelboraf (vemurafenib), is included in guidelines for cutaneous melanoma patients with unresectable or metastatic disease harboring a BRAF V600 mutation (PMID: 39550033; ESMO.org). detail... 39550033
BRAF V600X skin melanoma sensitive Binimetinib + Encorafenib Guideline Actionable BRAF inhibitor plus MEK inhibitor combination therapy, such as Mektovi (binimetinib) plus Braftovi (encorafenib), is included in guidelines for cutaneous melanoma patients with unresectable or metastatic disease harboring a BRAF V600 mutation (PMID: 39550033; ESMO.org). detail... 39550033
NRAS act mut skin melanoma sensitive Binimetinib Guideline Actionable Mektovi (binimetinib) is included in guidelines as subsequent therapy for patients with NRAS-mutant unresectable or metastatic cutaneous melanoma who did not benefit from prior immunotherapies (PMID: 39550033; ESMO.org). detail... 39550033
BRAF V600X skin melanoma sensitive Dabrafenib + Trametinib Guideline Actionable BRAF inhibitor plus MEK inhibitor combination therapy, such as Tafinlar (dabrafenib) plus Mekinist (trametinib), is included in guidelines for cutaneous melanoma patients with unresectable or metastatic disease harboring a BRAF V600 mutation (PMID: 39550033; ESMO.org). 39550033 detail...