Reference Detail

Ref Type

PMID

Authors

Cong Li, Lingming Liang, Liqin Liu, Zhen Xia, Zhihong Li, Xianghong Wang, Lawrence McGee, Angus Sinclair, Sasha Kamb, Dineli Wickramasinghe, Sachie Marubayashi, Juan C. Jaen, Jordan S. Fridman, and Kang Dai

Title

Abstract 787: FLX925 (AMG 925) is a rationally designed FLT3, CDK4/6 inhibitor that retains potency against clinically relevant secondary resistance mutations in FLT3

Journal	Vol	Issue	Date	Pages	Journal Short Title
Cancer Research

URL

http://cancerres.aacrjournals.org/content/75/15_Supplement/787.short

Abstract Text

Cancer Res August 1, 2015 75; 787

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Molecular Profile	Treatment Approach
No data available in table

Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Therapy Name	Drugs	Efficacy Evidence	Clinical Trials
FLX925	FLX925	1	1

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
FLX925		AMG925\|AMG-925\|AMG 925	CDK4/6 Inhibitor 14 FLT3 Inhibitor 69	FLX925 (AMG925) binds to and inhibits both FMS-related tyrosine kinase 3 (FLT3) and cyclin-dependent kinases 4 and 6 (CDK4/6), resulting in cell cycle arrest and inhibition of cell proliferation (Cancer Res 2015;75(15 Suppl):Abstract nr 787, PMID: 25326874).

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Gene	Variant	Impact	Protein Effect	Variant Description	Associated with drug Resistance
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
FLT3 Y599_D600insSTDNEYFYVDFREYEY	acute myeloid leukemia	predicted - sensitive	FLX925	Preclinical	Actionable	In a preclinical study, acute myeloid leukemia cells harboring a FLT3-ITD secondary resistance mutation demonstrated sensitivity to FLX925 (Cancer Res, August 1, 2015 75; 787).	detail...

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