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Ref Type Journal Article
PMID (41297162)
Authors Kuemmel S, Jung KH, Andrade L, Assad-Suzuki D, de la Cruz Merino L, Freitas-Junior R, Hegg R, Huang CS, Martin H, Schneeweiss A, Dieterich M, Nguyen Duc A, Feng Y, Meng R, Swat A, Seiller A, Bermejo B, Hamilton EP
Title Safety and efficacy of tiragolumab, atezolizumab and chemotherapy for early-stage or PD-L1-positive advanced triple-negative breast cancer: a phase Ib study.
Journal Vol Issue Date Pages Journal Short Title
ESMO open 10 12 2025 Dec 105869 ESMO Open
URL
Abstract Text Immune checkpoint inhibitors have transformed the management of triple-negative breast cancer (TNBC) but outcomes could be improved further. We explored combining the T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) inhibitor tiragolumab with atezolizumab-containing regimens for patients with early-stage or advanced TNBC.This multinational open-label phase Ib study included two cohorts. In cohort A [programmed death-ligand 1 (PD-L1)-positive advanced TNBC], patients received first-line tiragolumab with atezolizumab and nab-paclitaxel. The primary endpoint was confirmed objective response rate. In cohort B (early-stage TNBC, irrespective of PD-L1 status), patients were randomised to receive tiragolumab, atezolizumab and sequential taxane- and anthracycline-based neoadjuvant therapy with (arm A) or without (arm B) carboplatin. The primary objective was to evaluate safety in arm A versus arm B.Between September 2020 and October 2021, 83 patients were enrolled from 24 sites in eight countries. In cohort A (n = 41), the confirmed objective response rate was 54% [95% confidence interval (CI) 37% to 69%], median duration of response in 22 responding patients was 7.2 months (95% CI 4.9-13.1 months), median progression-free survival was 6.5 months (95% CI 5.4-9.0 months) and median overall survival was 24.6 months (95% CI 14.7 months-not estimable). Five patients (12%) discontinued tiragolumab for adverse events. In cohort B (n = 42), carboplatin was associated with more haematological effects but no increase in pathologic complete response rate [arm A: 46% (95% CI 24% to 68%); arm B: 55% (95% CI 32% to 77%)]. Adverse events led to treatment discontinuation in 23% and 20% of patients in arms A and B, respectively.The activity of tiragolumab-containing regimens appeared similar to that of atezolizumab plus chemotherapy in randomised phase III trials in early-stage and advanced TNBC. The safety profile of all three regimens was consistent with previous experience of similar regimens in other tumour types and with symptoms of the underlying disease.ClinicalTrials.gov NCT04584112.

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CD274 positive triple-receptor negative breast cancer no benefit Atezolizumab + Nab-paclitaxel + Tiragolumab Phase I Actionable In a Phase Ib trial, the addition of Tiragolumab (MTIG7192A) to first-line Tecentriq (atezolizumab) and Abraxane (nab-paclitaxel) combined treatment resulted in a similar objective response rate of 54% compared to historical control without Tiragolumab (MTIG7192A), a median duration of response of 7.2 months, median progression-free survival of 6.5 months, and median overall survival of 24.6 months in patients with CD274 (PD-L1)-positive triple-negative breast cancer (PMID: 41297162; NCT04584112). 41297162