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Ref Type Journal Article
PMID (39263341)
Authors Schöffski P, Sciot R, Debiec-Rychter M, Van Ongeval J, D'Hoore A, Merckx L, Joniau S
Title Successful Perioperative and Surgical Treatment of a Rare Case of Extra-Gastrointestinal Stromal Tumor Arising in the Prostate Gland.
Journal Vol Issue Date Pages Journal Short Title
Case reports in oncology 12 1 2019 Jan-Apr 183-191 Case Rep Oncol
URL
Abstract Text We report a very uncommon case of a primary, non-metastatic gastrointestinal stromal tumor (GIST) arising in the prostate gland in a 60-year-old patient. The morphology and immunohistochemical profile of the disease resembled GIST of gastrointestinal origin, and the molecular driver of this malignancy was a double mutation in exons 11 and 13 of the KIT gene. The tumor was proliferating slowly, did respond to neoadjuvant therapy with the KIT-inhibiting agent imatinib and was cured by radical, retro-pubic prostatectomy followed by adjuvant imatinib treatment. We postulate that primary GIST tumors of the prostate can arise from prostatic interstitial cells, which are the pacemakers of smooth muscle contractility in the gland, and possibly share a common precursor with typical GIST and the interstitial cells of Cajal in the gastrointestinal tract.

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
KIT G565R missense unknown KIT G565R lies within the cytoplasmic domain of the Kit protein (UniProt.org). G565R has been identified in the scientific literature (PMID: 39263341, PMID: 29657615, PMID: 30651371), but has not been biochemically characterized and therefore, its effect on Kit protein function is unknown (PubMed, Apr 2026).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT G565R KIT K642E gastrointestinal stromal tumor predicted - sensitive Imatinib Case Reports/Case Series Actionable In a clinical case study, Gleevec (imatinib) treatment resulted in a partial metabolic response in a patient with gastrointestinal stromal tumor in the prostate harboring KIT G565R and K642E (PMID: 39263341). 39263341