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Authors | Bernard Barlaam | ||||||||||||
Title | Discovery of AZD8835, a potent and selective inhibitor of PI3K? and PI3K? for the treatment of PIK3CA-dependent cancers | ||||||||||||
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URL | http://cancerres.aacrjournals.org/content/75/15_Supplement/2830.short | ||||||||||||
Abstract Text | AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2830 |
Molecular Profile | Treatment Approach |
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Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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PIK3CA H1047R | ovarian cancer | sensitive | AZD8835 | Preclinical | Actionable | In a preclinical study, AZD8835 inhibited tumor growth in mouse xenografts of ovarian cancer with a Pik3ca H1047R mutation (AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2830). | detail... |