Therapy Detail

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Therapy Name	AZD8835
Synonyms
Therapy Description	AZD8835 inhibits PIK3CA and PIK3CD, potentially resulting in decreased growth of PI3K-dependent tumors (PMID: 26839307, PMID: 32194423).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
AZD8835		AZD-8835\|AZD 8835	PIK3CA inhibitor 26 PIK3CD inhibitor 27	AZD8835 inhibits PIK3CA and PIK3CD, potentially resulting in decreased growth of PI3K-dependent tumors (PMID: 26839307, PMID: 32194423).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
PIK3CA E545K	estrogen-receptor positive breast cancer	sensitive	AZD8835	Preclinical	Actionable	In a preclinical study, AZD8835 inhibited proliferation of estrogen receptor (ER)-positive breast cancer cells harboring PIK3CA E545K in culture and suppressed tumor growth in xenograft models (PMID: 26839307).	26839307
PIK3CA H1047R	ovarian cancer	sensitive	AZD8835	Preclinical	Actionable	In a preclinical study, AZD8835 inhibited tumor growth in mouse xenografts of ovarian cancer with a Pik3ca H1047R mutation (AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2830).	detail...
PIK3CA K111N	estrogen-receptor positive breast cancer	sensitive	AZD8835	Preclinical	Actionable	In a preclinical study, AZD8835 inhibited proliferation of estrogen receptor (ER)-positive breast cancer cells harboring PIK3CA K111N in culture and induced tumor regression in xenograft models (PMID: 26839307).	26839307
PIK3CA mutant	estrogen-receptor positive breast cancer	sensitive	AZD8835	Preclinical	Actionable	In a preclinical study, AZD8835 inhibited proliferation of estrogen receptor (ER)-positive breast cancer cells harboring PIK3CA mutations in culture and suppressed tumor growth in xenograft models (PMID: 26839307).	26839307
PIK3CA mutant	breast cancer	sensitive	AZD8835	Preclinical	Actionable	In a preclinical study, AZD8835 inhibited tumor growth in breast cancer xenograft models harboring PIK3CA mutations (AACR; 2015. Abstract nr 2665).	detail...
PIK3CA mutant	Advanced Solid Tumor	sensitive	AZD8835	Preclinical	Actionable	In a preclinical study, AZD8835 inhibited growth of a variety of advanced solid tumor models with Pik3ca mutations in culture (PMID: 26839307).	26839307
PIK3CA wild-type PTEN loss	breast cancer	resistant	AZD8835	Preclinical	Actionable	In a preclinical study, human breast cancer cells with wild-type PIK3CA and loss of PTEN were resistant to growth inhibition by AZD8835 in culture (PMID: 26839307).	26839307

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT02260661	Phase I	Fulvestrant AZD8835	Phase I, Dose Study to Look at the Safety and Pharmacokinetics of AZD8835 in Patients With Advanced Solid Tumours	Completed	USA \| GBR	0

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