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Ref Type
PMID
Authors A.E. Drilon, B.C. Cho, J.J. Lin, B.J. Solomon, C.-C. Lin, A.J. de Langen, E. Felip, J.W. Neal, S.V. Liu, R.A. Soo, S. Kao, J. Wolf, G. Liu, C.S. Baik, C. Dooms, M. Nagasaka, A.J. van der Wekken, D.R. Camidge, T. Yoshida, C.-C. Lin
Title PL02.15 Pivotal ARROS-1 Efficacy and Safety Data: Zidesamtinib in TKI Pre-treated Patients with Advanced/Metastatic ROS1+ NSCLC
Journal Vol Issue Date Pages Journal Short Title
Journal of Thoracic Oncology 20 10, Suppl 1 Oct 2025 S3 J Thor Oncol
URL https://www.sciencedirect.com/science/article/abs/pii/S1556086425010688
Abstract Text See https://flasco.org/wp-content/uploads/FLASCO-2025_-ARROS-1-Encore-Data_Poster_20Oct2025.pdf for full content

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ROS1 fusion lung non-small cell carcinoma predicted - sensitive Zidesamtinib FDA approved Actionable In a Phase I trial (ARROS-1) that supported FDA approval, Jideytro (zidesamtinib) treatment demonstrated safety and activity in patients with locally advanced or metastatic ROS1-positive non-small cell lung cancer who have received prior ROS1 TKI, resulting in an overall response rate (ORR) of 44% (51/117), duration of response rate of 84% at 6 mo, 78% at 12 mo, and 62% at 18 mo, with respective progression-free survival rate of 57%, 48%, and 40% (J Thor Oncol (2025) 20 (10, Suppl_1): S3; NCT05118789). detail... detail...