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Therapy Name NUV-520
Synonyms
Therapy Description

NUV-520 is small molecular inhibitor of ROS1 that potentially penetrates the brain, and may result in reduced ROS1 kinase activity, decreased cell growth, and antitumor activity (Cancer Res 2021;81(13_Suppl):Abstract nr 1465).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
NUV-520 NVL-520|NUV 520|NUV520|NVL 520|NVL520|SIM18031A ROS1 Inhibitor 21 NUV-520 is small molecular inhibitor of ROS1 that potentially penetrates the brain, and may result in reduced ROS1 kinase activity, decreased cell growth, and antitumor activity (Cancer Res 2021;81(13_Suppl):Abstract nr 1465).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ROS1 fusion lung non-small cell carcinoma predicted - sensitive NUV-520 Phase I Actionable In a Phase I trial (ARROS-1), NUV-520 treatment resulted in 6 partial responses among 12 patients with non-small cell lung cancer harboring a ROS1 fusion including a partial response in 5 of 7 patients harboring a ROS1 fusion with ROS1 G2032R (Eu J Cancer 2022 Vol 174, Supp 1:S6-S7; NCT05118789). detail...
ROS1 fusion ROS1 G2032R lung non-small cell carcinoma predicted - sensitive NUV-520 Phase I Actionable In a Phase I trial (ARROS-1), NUV-520 treatment resulted in 6 partial responses among 12 patients with non-small cell lung cancer harboring a ROS1 fusion including a partial response in 5 of 7 patients harboring a ROS1 fusion with ROS1 G2032R (Eu J Cancer 2022 Vol 174, Supp 1:S6-S7; NCT05118789). detail...
ROS1 D2113G Advanced Solid Tumor sensitive NUV-520 Preclinical - Cell culture Actionable In a preclinical study, NUV-520 inhibited proliferation of transformed cells expressing ROS1 D2113G in culture (PMID: 37587872). 37587872
ROS1 D2113N Advanced Solid Tumor sensitive NUV-520 Preclinical - Cell culture Actionable In a preclinical study, NUV-520 inhibited proliferation of transformed cells expressing ROS1 D2113N in culture (PMID: 37587872). 37587872

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05118789 Phase Ib/II NUV-520 A Study of NVL-520 in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1) Recruiting USA | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUS 4


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