Reference Detail

Ref Type

PMID

Authors

Jean-Yves Blay, Lin Shen, Yoon-Koo Kang, Piotr Rutkowski, Shukui Qin, Dmitry Nosov, Steven C. Novick, Lilia Taningco, Shuyuan Mo, Peter Reichardt and George D. Demetri

Title

Phase III trial of nilotinib versus imatinib as first-line targeted therapy of advanced gastrointestinal stromal tumors (GIST)

Journal	Vol	Issue	Date	Pages	Journal Short Title
Journal of Clinical Oncology

URL

http://meeting.ascopubs.org/cgi/content/abstract/31/15_suppl/10501

Abstract Text

J Clin Oncol (Meeting Abstracts) May 2013 vol. 31 no. 15_suppl 10501

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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
KIT exon11	gastrointestinal stromal tumor	sensitive	Nilotinib	Phase III	Actionable	In a Phase III trial, a 24 month progression free survival was observed in 69.6% of advanced GIST patients harboring KIT exon 11 mutations when treated with Tasigna (nilotinib) (J Clin Oncol May 2013 vol. 31 no. 15_suppl 10501).	detail...

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