Reference Detail

Ref Type

PMID

Authors

M. Heinrich, R. Jones, P. Schoffski, S. Bauer, M. von Mehren, F. Eskens, P. Cassier, O. MIr, H. Shi, T. Alvarez-Diez, M.E. Healy, B. Wolf, S. George

Title

Preliminary safety and activity in a first-in-human phase 1 study of BLU-285, a potent, highly-selective inhibitor of KIT and PDGFRa activation loop mutants in advanced gastrointestinal stromal tumor (GIST)

Journal	Vol	Issue	Date	Pages	Journal Short Title

URL

https://colectivogist.files.wordpress.com/2016/12/2016_1201_blu-285-slides.pdf

Abstract Text

https://colectivogist.files.wordpress.com/2016/12/2016_1201_blu-285-slides.pdf

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Molecular Profile	Treatment Approach
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Gene Name	Source	Synonyms	Protein Domains	Gene Description	Gene Role
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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
KIT exon17	gastrointestinal stromal tumor	sensitive	Avapritinib	Phase I	Actionable	In a Phase I trial, Ayvakit (avapritinib) demonstrated preliminary antitumor activity in gastrointestinal stromal tumor patients harboring KIT mutations, with reduced tumor burden in 38% (5/13) of patients, including 1 partial response and 4 stable diseases, and 3 of the 5 responding patients harbored KIT exon 17 mutations (EORTC-NCI-AACR 2016, Abs 6LBA).	detail...

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