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PMID
Authors Esther CW Breij, Sandra Verploegen, Andreas Lingnau, Edward N van den Brink, Maarten Janmaat, Mischa Houtkamp... Wim Bleeker, David Satijn, Paul Parren
Title Preclinical efficacy studies using HuMax-Axl-ADC, a novel antibody-drug conjugate targeting Axl-expressing solid cancers.
Journal Vol Issue Date Pages Journal Short Title
URL http://ascopubs.org/doi/abs/10.1200/jco.2015.33.15_suppl.3066
Abstract Text

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
AXL positive Advanced Solid Tumor predicted - sensitive Enapotamab vedotin Preclinical - Pdx Actionable In a preclinical study, Enapotamab vedotin (HuMax-Axl-ADC) inhibited tumor growth in solid tumor xenograft models, including induction of tumor regression in solid tumor patient-derived xenograft (PDX) models expressing Axl in a subset of tumor cells (J Clin Onc 2015 33:15_suppl, 3066). detail...